Discovery of a neutralizing antibody to treat covid-19
THE NEEDA number of therapeutic options have been explored over the course of the COVID-19 pandemic, yet there is still no effective treatment for hospitalized patients. It istherefore crucial to identify targets for antiviral intervention and elucidate critical viraland host determinants that play a central role in the development of severe disease. THE SOLUTIONFast track […]
Discovery of a therapeutic antibody for the treatment of inflammatory bowel disease and type I diabetes
THE NEEDPreventing apoptopic cell loss in IBD and insulin-dependent diabetes patientsInsulin-like growth factor binding-protein 3 (IGFBP3) binds to Transmembrane Receptor 219 (TMEM219) on intestinal stem cells (ISCs) and pancreatic beta cells and mediates cell death/apoptosis in an IGF1-independent way. Dysregulation of the IGFBP3/TMEM219 axis, due to increased levels of circulating free IGFBP3, plays a key role […]
