While conventional combinatorial libraries remain highly effective for a wide range of targets and offer significant diversity, paired antibody libraries enable the discovery of more functional antibodies with higher affinities, especially for complex or structurally demanding targets such as glycans.
In this case study, we have identified over 1,000 glycan-specific clones using paired libraries compared to just seven from a combinatorial library, demonstrating the power of preserving natural VH/VL pairing.
Our paired libraries approach ensures full coverage of the natural immune repertoire, supports unlimited re-screening, and allows in vitro selection for complex binding profiles.
