The power of in-vitro antibody selection
The selection is completely independent of animal immunizations and helps to reduce unnecessary animal experiments. Moreover, bypassing the in-vivo immune response has many advantages, particularly for difficult targets like highly conserved, non-immunogenic, instable, or toxic proteins.
YUMAB can tightly control biochemical conditions to guide antibody selection towards higher specificity and lower cross-reactivity, respectively. Specificity and cross-reactivity can even be targeted to certain epitopes, e.g. shared epitopes of the human and murine protein. We can also match your final assay conditions (e.g., buffer, salt, pH, allosteric conformation of the antigen, competitors, etc.) during in-vitro selection to generate antibodies that will work better for your application.